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| Division of Human Stem Cell Technology (Yoshiki Sasai) |
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Yoshiki Sasai M.D., Ph.D.
(Deputy Unit Leader Masatoshi Ohgushi Ph.D.)
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Human Stem Cell Technology Unit (Yoshiki Sasai)
Research Areas
Stem cells - both embryonic and somatic - can be challenging to study and manipulate in vitro. The Division of Human Stem Cell Technology Unit was established to provide a full spectrum of support services to labs within the CDB and throughout Japan with an interest in using human embryonic stem cells (hESCs) and their derivatives in their research. The unit provides expertise, training, and support in hESC culture, maintenance, distribution and management, for users in the life sciences community. We seek to contribute to achieving the goals of translational research, in line with the CDB mission to establish a solid scientific foundation for regenerative medicine.
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Yoshiki Sasai M.D., Ph.D.
(Deputy Unit Leader Mototsugu Eiraku Ph.D.) |
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Four-dimensional Tissue Analysis Unit
(Yoshiki Sasai)
Research Areas
Recent advances in stem cell technology have enabled the generation of various potentially medically useful cell types from ES and iPS cells, including neurons, photoreceptors, and cardiac muscle. However, the extent to which such cells mimic their in vivo function when plated on culture dishes is limited. The four-dimensional tissue analysis unit seeks to develop new approached to cell technology that will allow for more realistic in vitro recapitulation through three-dimensional tissue formation from stem cells. To this end, we establish efficient three-dimensional culture of ES cell-derived brain and retinal tissues, and also develop new cutting-edge live imaging technology and related optic devices for four-dimensional analysis of relatively large tissues. We also support and collaborate with CDB and non-CDB users of these optics technologies.
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Science Policy and Ethics Studies Unit (Douglas Sipp)
Research Areas
The field of stem cell research has received a great deal of attention due to the combination of fundamental scientific interest, therapeutic promise, and commercial potential it entails. But it has also been surrounded by legal, social, and ethical tensions across a broad range of issues, from the research use of human embryos to the optimization of pathways for the translation of basic research into clinical applications. We will seek to compare different science policy approaches to these issues and identify regulatory frameworks best suited to the development and promulgation of stem cell applications. We will further explore social and ethical perspectives on the translation of human stem cell research, with an emphasis on the Asia-Pacific region.
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Human Stem Cell Technology Unit
Ohgushi, M., et al. Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Embryonic Stem Cells. Cell Stem Cell 7, 225-239 (2010)
NagaseT, et al. Pericellular matrix of decidua-derived mesenchymal cells: a potent human-derived substrate for the maintenance culture of human ES cells. Dev Dyn 238. 1118-1130 (2009)
Four-dimensional Tissue Analysis Unit
Suga H, et al. Self-formation of functional adenohypophysis in three-dimensional culture. Nature (2011)
Danjo T, et al. Subregional specification of embryonic stem cell-derived ventral telencephalic tissues by timed and combinatory treatment with extrinsic signals. J Neurosci 31.1919-33 (2011)
Eiraku M, et al. Self-organized formation of polarized cortical tissues from ESCs and its active manipulation by extrinsic signals. Cell Stem Cell 3.519-32 (2008)
Science Policy and Ethics Studies Unit
Sipp D. Stem cells and regenerative medicine on the Asian horizon: an economic, industry and social perspective. Regen Med 4.911-8 (2009)
Sipp D. Gold standards in the diamond age: the commodification of pluripotency. Cell Stem Cell 5. 360-3 (2009)
Sipp D The rocky road to regulation. Nature Reports Stem Cells doi:10.1038/stemcells.2009.125(2009)
Sipp D Stem cell research in Asia: a critical view. J Cell Biochem 107. 853-6 (2009)
Kiatpongsan S and Sipp D Medicine. Monitoring and regulating offshore stem cell clinics. Science 323. 1564-5 (2009)
Kiatpongsan S and Sipp D Offshore stem cell treatments. Nature Reports Stem Cells doi:10.1038/stemcells.2008.151(2009)
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