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| Margaret T. Fuller received her B.A. in Physics from Brandeis University in 1974 and her Ph.D. in Microbiology from the Massachusetts Institute of Technology in 1980, where she worked with Jonathan King in examining how bacteriophage capsids are assembled. Dr. Fuller was a Jane Coffin Childs Postdoctoral Fellow with Drs. Elizabeth Raff and Thomas Kaufman in the Department of Biology, Indiana University, from 1980-1983, where she began her work in cell biology and developmental genetics, carrying out a genetic analysis of microtubule structure and function during spermatogenesis in Drosophila. Dr. Fuller was an assistant, then associate professor in the Department of Molecular, Cellular and Developmental Biology, University of Colorado at Boulder from 1983-1990, when she moved to the newly formed Department of Developmental Biology at Stanford University School of Medicine, with a joint appointment in the Department of Genetics. A Searle Scholar from 1985-88 and elected to the American Academy of Arts and Sciences in 2006, Dr. Fuller is currently the Chairman of the Department of Developmental Biology and Reed-Hodgson Professor of Human Biology at Stanford. Dr. Fuller's research investigates the mechanisms that regulate how germ cells differentiate from stem cell precursors. Her work helped define the role of the support cell microenvironment - the stem cell niche - in specifying stem cell self-renewal, and the role and mechanisms of oriented cell division that specify the normally asymmetric outcome of stem cell divisions in the male germ line. Studies from her laboratory continue to reveal how expression of terminal differentiation genes is kept off in precursor cells and how this repression is reversed to allow cells to differentiate. |
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